Stress granules
نویسندگان
چکیده
What are stress granules? Stress granules are non-membranous cytoplasmic foci ranging in size from 0.1 to 2.0 μm, composed of non-translating messenger ribonucleoproteins (mRNPs) that rapidly aggregate in cells exposed to adverse environmental conditions. Their assembly is triggered by a variety of environmental stresses including heat shock, oxidative stress, hyperosmolarity, viral infection, and UV irradiation, but not X-irradiation or DNA-damaging agents. Their mRNA composition is selective — they contain transcripts encoding housekeeping genes but exclude those encoding stress-induced genes such as HSP70. Stress granules are found in both cultured cell lines and intact tissues.
منابع مشابه
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ورودعنوان ژورنال:
- Current Biology
دوره 19 شماره
صفحات -
تاریخ انتشار 2009